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246 In comparison to the primary site, breast cancer metastases (including lymph nodes, lung, liver, and brain) also undergo substantial immune reprogramming with an augmented presence of immunosuppressive cells and compromised antitumor immunity
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An increase in ROS accelerates tumor cell death, while GSH, as a key component in redox homeostasis, plays a crucial role in scavenging ROS and neutralizing exogenous metabolites in tumor cells [15]
Crack PJ, Cimdins K, Ali U, Hertzog PJ, Iannello RC