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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted

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These effects should be combined with the BPC 157 ability to counteract alcohol intoxication, both acute and chronic (22, 24) (commonly believed to be relevant to the disturbances induced by morphine application (5)