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Additionally, the short intraocular half-life of most ferroptosis modulators, which is less than 1.5 hours in the aqueous humor, necessitates frequent administration, further reducing patient compliance (160)

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In addition, we found that autophagy is activated in the process of ferroptosis and reduces SIPS, suggesting an essential role of autophagy in ferroptosis and SIPS

Previous studies have reported that MOR on intestinal neurons contributes to opioid-induced constipation 8,9,10