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Prescribing decisions are made by physicians on an individual basis following a thorough clinical assessment of the patient's history, condition, imaging where relevant, and prior treatments

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FasL binding induces the trimerization of Fas, which recruits the adaptor protein FADD (Fas-associated death domain) and the initiator caspase-8 or caspase-10, which are oligomerized and activated through autocatalysis

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It is noteworthy that miR-181 family members, especially the miR-181a-3p, are among the 76 miRNAs suggested to be oncogenic in CRC, according to a study conducted by Yuan et al (138)