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These include blood concentrations of total cobalamin, holo-transcobalamin (vitamin B 12 bound to transcobalamin, one of the two carrier proteins in blood

Individuals over the age of 50 years should augment their dietary intake with vitamin B 12 from supplements or fortified foods because of the increased likelihood of food-bound vitamin B 12 malabsorption with advanced age

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B12 is primarily found in animal-based foods such as meat, dairy, and eggs, and is absorbed in the small intestine after binding to a protein

Adipose triglyceride lipase-null mice are resistant to high-fat dietinduced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation