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These results approach the efficacy of Roux-en-Y gastric bypass surgery, which typically produces 25-30% weight loss at one year

PAGln is also a common toxin in CKD, significantly accumulating in CKD patients and associated with overall mortality and cardiovascular disease (129), linking gut microbiota metabolism, CKD, and cardiovascular complications

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The degree of vascular permeability, the density and composition of the extracellular matrix and the balance of immune cell subsets differ across tumor types, among patients with the same diagnosis and between individual lesions in one patient [115]

Molecules (2018) 23:624