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10.1016/j.athoracsur.2010.01.048 193

Micro computed tomography Rats (n=12) were anaesthetized again and the mandibles were excised, separated from the surrounding tissues and cut in half in a sagittal plane between the incisors and were processed

At the joint microenvironment level, analyses of synovial fluid and cartilage tissue samples from OA patients, as well as studies in surgically induced such as the DMM model or chemically induced animal OA models, consistently observe clear iron metabolism abnormalities and significant iron accumulation locally in affected joints

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