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The high activity of 30 prompted a synthesis of the corresponding disulfide 32 with a 14-membered ring system anticipated be able to adopt a similar trans conformation as 30

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[1] Cell Line:Senescent Leydig cells Concentration:25 mM Incubation Time:3 days Result:Reduced the viability of senescent as compared to normal TM3 Leydig cells

Bzducha-Wrbel A, Baejak S, Kieliszek M, Pobiega K, Falana K, Janowicz M (2018) Modification of the cell wall structure of Saccharomyces cerevisiae strains during cultivation on waste potato juice water and glycerol towards biosynthesis of functional polysaccharides

MBOAT1 could selectively decrease cellular levels of PE-PUFA (polyunsaturated fatty acid), which is the preferred substrate for peroxidation to induce ferroptosis, and thus suppresses ferroptosis in a GPX4 -independent manner 54