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( B ) Heatmap of GSH pathway metabolites intensity normalized by row as a z score from A549shNRF2-BIND-luc cells treated with 1 M A-485 for 24 h

For example, in order to maintain intracellular redox homeostasis and build a powerful antioxidant defense, cancer cells are typically characterized by high level of antioxidants, especially GSH with a high concentration of 10 mM, which is approximately ten times higher than that in normal cells (Forman et al., 2009)

All subjects were divided into different groups, where one group was presented with the peptide gel, whereas others were given standard care with a placebo application

Decreased GSH then results in lipid peroxide accumulation and induction of ferroptosis

[DOI] [PubMed] [Google Scholar] 59.Philips S.A., Thornalley P.J