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Aldh2*2 KI mice were obtained by breeding male and female Aldh2*2 KI homozygous mice while age-matched WT C57BL/6NJcl mice were obtained from CLEA Japan Inc

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Consequently, inhibiting ACSL4 expression represents an important direction in ferroptosis research ( The final step of PUFA-PE peroxidation requires lipoxygenase catalysis, suggesting a potential role for these enzymes in ferroptosis induction

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