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The authors speculate that their analysis might have under estimated the true difference in relative risk between the sexes, since in many regions women have only started to smoke in large numbers in recent years

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Spirometric measures lead to a progressive loss of lung function as measured by forced expiratory volume in 1 s (FEV1) and FEV1 divided by forced vital capacity (FVC) FEV1/FVC ratio

But these are at very low levels or under strict safety regulations