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A unique AANAT activity does not necessarily coincide with the circadian biosynthetic rhythm of pinealocytes, but could be subjected to the demands of surrounding tissues [11]

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Taken together, there is no doubt that measurement of endothelial function provides substantial prognostic information about future cardiovascular events in atherosclerotic disease and hypertension, whereas its role in primary prevention and whether the introduction of novel methods to assess endothelial function will further increase its prognostic potential 52 remains to be established

Confirming or excluding interference Discordance between the result and the clinical picture raises the possibility of assay interference

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