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When the requirement for NADPH outweighs the need for ribose, for example in adipose tissue where there is a large demand for NADPH for fatty acid biosynthesis, the pathway operates as a cycle, generating NADPH and CO2 and returning 5/6 of the carbon to the glycolysis pathway via fructose-6-phosphate and glyceraldehyde-3-phosphate

Interestingly, SRY can also be expressed in brain, particularly in catecholaminergic cells and neurons, suggesting a modulatory role in physiological conditions, such as hypertension (45)

Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls