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The ingestion of a high-calorie diet or the consumption of substantial amounts of alcohol has been demonstrated to promote DNL through the activation of two transcription factors: carbohydrate response element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c)
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Anti-inflammatory peptides typically target more specific pathways NF-kB signaling, mitochondrial ROS, or sirtuin activation which may offer more selective anti-inflammatory effects
Those prioritizing convenience may simply rotate through standard sites without concern for proximity to target fat areas
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