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This research has, however, some limitations including that it uses self-reported data susceptible to social desirability biases, that it is cross-sectional and thus does not allow for causal inference, that it is subject to residual confounding, and that it was conducted using only US data, which limits its generalizability for adult LCC users in other countries

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History [edit] Origins [edit] James Buchanan Duke's entrance into the cigarette industry came about in 1879 when he elected to enter a new business rather than face competition in the shredded pouched smoking tobacco business against the Bull Durham brand, also from Durham, North Carolina