Although both semaglutide and cagrilintide induce satiety, they exert their effects in different regions of the brain, suggesting a synergistic effect on appetite regulation, warranting the investigation of these drugs as a combination therapy
Human and animal metabolism runs with great efficiency, squeezing the most from few calories
This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier
Key Features: Mimics ghrelin to increase GH pulse amplitude Does not significantly raise ACTH, prolactin, or cortisol Very low risk of water retention, appetite spikes, or gynecomastia Well-tolerated in both men and women As a standalone peptide, Ipamorelin can modestly boost GH output
What Are NAD Injections and How Do They Work
