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Baier and Dietz 1997

If results remain unexplained, particularly with very high levels, further investigation may include imaging or haematology referral depending on clinical context and associated abnormalities

However, under moderate activation, microglia have a neuroprotective role by the release of anti-inflammatory mediators, such as Arg1, IL-4, IL-10, TGF-beta, CCL17, interferon growth factor 1 (IGF-1), GDNF, BDNF, platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) (reviewed in [29,40,41])

J Biol Allied Health Sci

During the pathogenesis of OA, JUN directly binds to the promoter of NCOA4 and initializes its transcription, increasing ferritinophagy degradation, leading to ferroptosis and extracellular matrix degradation in chondrocytes