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Our study is the first to identify a dose-response relationship between vitamin B12 and clinical pregnancy: among women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, clinical pregnancy rates increase with rising serum vitamin B12 levels up to a threshold of approximately 358.7 pg/mL

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Sonigo C, et al

Folate is converted into its active form (5-methyltetrahydrofolate) through the folate cycle, and MTHFR is directly responsible for the creation of folates active form

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