2.2 Recognizing B12 Deficiency Suboptimal B12 may present subtly: Neurological : Paresthesias in hands or feet, gait instability, cognitive fogginess. Psychiatric : Mood swings, irritability, depression
Common signs of B12 deficiency include persistent fatigue and weakness, related to anemia caused by impaired red blood cell production
B12 shots deliver a concentrated amount of cobalamin, a water-soluble vitamin essential for red blood cell formation, neurological function, and DNA synthesis, as detailed in the NIH fact sheet on vitamin B12
If oral B12 replacement has been trialled in a person with metformin-associated B12 deficiency, I would suggest that a repeat measurement of B12 levels after 812 weeks is a good time to reassess whether absorption is adequate or whether a switch to intramuscular replacement is required
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