The active factor was isolated and identified as this small peptide with a strong affinity for copper(II) ions
After proteolysis cleavage, the newly formed C-terminus of c-MET -chain inserts into a small pocket in HGF I-K1, which is mainly stabilized by the electrostatic interaction between Glu302 of c-MET and Arg197 of HGF (Fig
Dathe M, Wieprecht T, Nikolenko H, Handel L, Maloy WL, MacDonald DL, Beyermann M, Bienert M: Hydrophobicity, hydrophobic moment and angle subtended by charged residues modulate antibacterial and haemolytic activity of amphipathic helical peptides
Marcel Dekker, Inc, 401-420, 1990
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