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Gluten degradation, pharmacokinetics, safety, and tolerability of TAK-062, an engineered enzyme to treat celiac disease

It is indicated to reduce serum phosphorus in adults with chronic kidney disease (CKD) on dialysis who have an inadequate response to phosphate binders or who are intolerant of any dose of phosphate binder therapy

Woodman AG, Mah R, Keddie DL, Noble RM, Holody CD, Panahi S, et al

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Cytochrome P450 and glutathione S -transferase confer metabolic resistance to SYP-14288 and multi-drug resistance in Rhizoctonia solani