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Indeed, this system accounts for approximately 20% of abluminal Na-dependent Gln transport activity, whereas system N mediates the majority of Gln transport across the abluminal membrane ( Transport of Large and Small Neutral AAs: System ASC This is a Na + -dependent system located exclusively on the luminal membranes of the BBB, whose name ASC was derived from the three main substrates Ala, Ser, and Cys, although Gly and several essential AAs are also putative substrates, including Met, Val, Leu, Iso, and Thr (Tayarani et al., 1987)

Optimal results typically appear 4-8 weeks after completing the initial series, with continued improvement up to 3 months as collagen remodeling continues

doi: 10.1093/jn/134.11.3054

It plays a natural role in tissue repair, anti-inflammatory signalling, and collagen regulation