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This extended urinary detection suggests continued metabolism of tissue-bound peptide or slow release from tissue reservoirs

10.1016/j.mtbio.2021.100121 121 WalshM

Multi-target combination therapies could be applied in GC treatment, for example, TGF- blockers in combination with PD-1/PD-L1 inhibitors, or sequential therapies, such as blocking TGF- or IL-6 first to release the immunosuppressive microenvironment, followed by the administration of immune checkpoint inhibitors