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Cadmium-induced astroglial death proceeds via glutathione depletion

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Also, in vitro studies indicate that the responsiveness of pro-B cells to IL-7 is compromised in aged individuals [355], and IL-7 release from stromal cells in the bone marrow also declines with age [356], leading to reduced pro B-cell proliferation

Low B12 doesnt directly cause weight gain, but chronic fatigue and slow metabolism from a deficiency may lead to reduced activity levels, contributing to weight gain over time