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This peptide also influences the pineal gland, potentially boosting melatonin production, which plays a role in immune regulation

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Both C5a and C3a enhance vascular permeability, resulting in plasma exudation and joint swelling

ROS are directly or indirectly associated with cytokine storm induction in SARS-CoV-2 infection, and ROS can activate NF-B and NLRP3 inflammasomes, thereby leading to the production of inflammatory cytokines and the development of acute respiratory distress syndrome and multiple organ dysfunction 62,63,64