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When Symptoms Worsen: Understanding the Adjustment Period The period following B12 injection therapy can be challenging for some patients, with symptoms sometimes temporarily intensifying before improvement becomes apparent

Abbreviations ADHD: Attention Deficit/Hyperactivity Disorder D2R: Dopamine D2 Receptor DAT: Dopamine Transporter SD: Sprague-Dawley Rats SHR: Spontaneously Hypertensive Rats WKY: Wistar Kyoto rats NAc: Nucleus accumbens core References Polanczyk GV, Salum GA, Sugaya LS, Caye A, Rohde LA

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[36] [37] [38] A long-term study where vitamin B 12 was supplemented across a period of 10 years, led to lower levels of weight gain in overweight or obese individuals (p 20% of elderly individuals showed evidence of marginal vitamin B 12 depletion (serum vitamin B 12 : 148221 pmol/L)

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