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Akiyama H, Zhao R, Nishida Y, Ostermann L, Mak PY, Ayoub E, Piya S, Carter B, Andreeff M , Ishizawa J

Platelet activation is caused by the breakdown of atheromatous plaque or the de-endothelialization of the arterial wall

Representative domains include: Gastrointestinal and hepatic models: Protection against ulcers, leaky gut, IBSlike symptoms, Crohntype inflammation, and toxic liver injury (e.g., CCl4, NSAID, and alcohol models), with improved mucosal healing and barrier integrity

M., Moore, C

Orr M, Guitart X, Karcz-Kubicha M, Solinas M, Justinova Z, Barodia SK et al (2013) Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans