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Finally, a direct relationship has been established between high-calorie diets and cancer risk, along with cancer prevention approaches through lifestyle modifications, including physical activity, exercise, and healthy diets rich in fruits, vegetables, and whole grains, while limiting red meat and saturated fat consumption

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Additionally, changes in subchondral bone contribute to cartilage destruction, primarily through an imbalance between osteoblastic and osteoclastic activity (Hu Y et al., 2021)