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While we are still a long way away from pinpointing an analogous pathogenic species in MS, once identified, a specific immunotherapy targeting the relevant misfolded proteins, rather than downstream immune effectors as is the current approach, could be more effective in the progressive stages of MS

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However, both genome-wide association studies (GWASs) and candidate gene studies have confirmed an important role for human leukocyte antigen (HLA) class I and class II genes in some but not all forms of DILI

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