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The active medication, the preservatives in the formulation, and the mechanical trauma from the needle all trigger mild inflammation at the injection site

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[DOI] [PubMed] [Google Scholar] Lorenz K, Lohse MJ, Quitterer U

In addition to inhibitory effects on the enzymes in TAG hydrolysis, insulin also decreases measurable rates of lipolysis (as indicated by the release of free fatty acids and glycerol from intact cells) by promoting the re-esterification of fatty acids (16)