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The source matters significantly for results

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Twelve (50%) patients in the proactive group and nine (36%) patients in the reactive group were at high risk of ODS

doi: 10.1016/0014-5793(88)80509-x

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)