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This finding triggered the amyloid hypothesis, which is the idea that APP cleavage products, such as A42, are the fundamental cause of AD, eventually leading to synaptic dysfunction, gliosis, neuronal loss, and tau pathology (Hardy, 2009)

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Liver histology Liver tissue was fixed overnight in 10% formaldehyde, transferred to 70% ethanol for 48 h and then processed into paraffin blocks