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Off-label veterinary use and animal studies indicate that it is in general well tolerated, although it is not FDA approved for dogs , and should only be used under veterinary supervision

Health Canada's regulation of cosmetics does not require pre-market approval for ingredients with established safety profiles when used in cosmetic products

Gumpricht, et al., 2000

Encephalopathy is caused by unconjugated bilirubin has the ability to pass through the blood-brain barrier, entering the central nervous system

While spirulina, dried nori, barley grass and most other seaweeds contain some B12 (dirt even contains some), consuming these foods hasnt been shown to provide enough B12 to vegans