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In the cytosol, acetyl-CoA can also be derived from acetoacetyl-CoA, which can originate from acetoacetate through the sequential actions of acetoacetyl-CoA synthetase (in an ATP-dependent manner) and subsequently the cytosolic isoform of acetoacetyl-CoA thiolase (Fig

In response to different extracellular stimuli, the complex may dissociate and JNK can phosphorylate c-Jun, a component of the activator protein-1 transcription factor

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