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However, the rapidly expanding body of research surrounding cellular bioenergetics and the redox cycle offers a beacon of realistic hope

This point is highly relevant, as one of the central roles of A is the modulation of synaptic plasticity (Parihar and Brewer, 2010), a process itself that is regulated by copper efflux into the synapse that can influence the excitability of NDMA, AMPA, and GABA receptors as well as vesicular trafficking (DAmbrosi and Rossi, 2015)

10.1590/18069061-2015-0155 151 KawaharaK.HohjohH.InazumiT.TsuchiyaS.SugimotoY

At the same time, the absence of Gsr and TrxR in these cells results in an oxidized cytosol in which Grx1-disulfide or Grx-SSG accumulates

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