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Lower 2,3-DPG level is associated with an increase in oxygen affinity and reduction in HbS polymerization, while increased RBC ATP may improve RBC membrane integrity and survival

False positives can occur in the following conditions, where elevated TMA can be present in the urine without any underlying TMAU: Urinary tract infection [22] Bacterial vaginosis [22] Cervical cancer [22] Advanced liver or kidney disease [22] A similar foul-smelling odor of the urine has also been associated with colonization of the urinary tract with a bacterium called Aerococcus urinae , especially in children

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The 60.3% symptom recurrence rate after discontinuation confirms that ongoing treatment appears necessary for sustained benefit