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Clinically, high levels of inflammatory markers are associated with the development of depression (83)

According to the model we have previously described, K ATP current activation driven by mitochondrial instability induces lability in the cellular action potential duration and alters the refractory period, which increases the dispersion of repolarization in the tissue and promotes reentrant arrhythmias through the formation of metabolic sinks [6, 7]

Azzouz et al

Shin splints develop when repetitive stress causes tiny tears or inflammation in the muscles and connective tissue surrounding the tibia

Metabolism 48, 677680