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With all these complex mechanisms involved in L-asparaginase resistance, it further strengthens our belief in using combination of chemotherapy rather than a single drug in treating cancers

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Indeed, increased levels of SAM in arterial cord blood (irrespective of treatment) and venous cord blood (mainly in the NAC-arm), were observed in severe IPTB, as well as higher serine, homocysteine, and methionine in maternal blood, along with similar levels of cystathionine in both maternal and cord blood

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In this case, cell lysates are incubated with a GST fusion protein, and subsequent GST pulldown experiments are performed 2