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Formulations of cyanocobalamin injection containing benzyl alcohol as a preservative should also be avoided in premature neonates and those with hypersensitivity due to its association with gasping syndrome (10-12)

In cases where freezing is absolutely necessary, the United Kingdom National Institute for Biological Standards and Control (NIBSC) recommends that researchers freeze and store aliquots of the peptide at -4F (-20C) or lower temperatures [17]

Should Reconstituted Solutions Be Frozen

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