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This can disrupt the usual replication of a cell, which again can lead to the development of cancer

PMID 21184833

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Regulatory and consumer taste challenges continue to plague the group, but valuations are very cheap, dividend yields are high, and the companies themselves are at various stages when it comes to diversifying away from tobacco

As such, the R-square from such a regression would be fairly close to one.[*] However, if smuggling is a prominent feature of the cigarette market, such a nave model will fail to explain a much larger percentage of the variation in per-adult sales, resulting in large residuals (in magnitude)