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Pharmacologic screening identifies metabolic vulnerabilities of CD8(+) T cells

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heterozygotes for cystinosis have half the cystine-transporting capacity [5] but never have any clinical manifestations of the disease [1, 2]

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doi: 10.1016/j.amjmed.2020.10.035 44

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5,36,37,38,39,40,41,42,43,44,45,46 PARP-1, accounting for approximately 90% of the NAD + used by the PARP family, has a lower K m for NAD + in the range of 2097 M

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People often associate thiols with molecules that can be off-putting, like 3-Methyl-2-butene-1-thiol, which smells like skunk and burnt rubber

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