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When adverse effects do occur following high-dose B12 administration, they are typically mild, transient, and often related to the route of administration rather than the vitamin itself

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del Rincon J-P, Iida K, Gaylinn BD, McCurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO

NNMT activity is known to increase as aging progresses or in response to certain lifestyle factors, often resulting in a decline in metabolic efficiency and a buildup of stubborn fat

If you see any of these, it could be a sign of contamination or that the peptide has not dissolved properly and should not be used in your research