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Access this article Similar content being viewed by others Abbreviations AcS: Nucleus accumbens shell ACC: Anterior cingulate cortex 42nAChR: Alpha 4 beta 2 nicotinic acetylcholine receptors 7nAChRs: Alpha 7 nicotinic acetylcholine receptors BDNF: Brain-derived neurotropic factor CaMKII: Calcium/calmodulin-dependent protein kinase II CHRNA4: Nicotinic acetylcholine receptor (Nachr) 4 subunit CPP: Conditioned placed preference CREB: cAMP response element binding D2RKO: Dopamine D2 receptor knockout DLS: Dorsolateral striatum D1R: Dopamine D1 receptors D2R: Dopamine D2 receptors ERK: Extracellular signal-regulated kinase LTP: Long-term potentiation MSN: Medium spiny neurons NAc: Nucleus accumbens NTRK2: Neurotrophic tyrosine kinase receptor 2 pCREB: Phosphorylation cAMP response element binding PK: Phosphokinase C PVDF: Polyvinylidene difluoride PtC: Parietal association cortex VTA: Ventral tegmental area WT: Wild type References Benowitz NL (1999) Nicotine addiction