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C.Agudelo-DelgadoM.TobnG

Progress will depend on decoupling lesion efficacy from systemic exposure through lesion-focused delivery platforms, triggerable or receptor-targeted prodrugs, and schedules or combinations that sustain lesion pressure at reduced doses

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To manage the risk of elevated transaminase levels, assess ALT and AST: within one month prior to initiation of XENPOZYME, within 72 hours prior to any infusion during dose escalation, which includes the first 3 mg/kg dose, or prior to the next scheduled XENPOZYME infusion upon resuming treatment following a missed dose

Oxidative stress / antioxidant-pathway investigations