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Tu et al., 2021)

Additionally, upregulated Notch binding and metallopeptidase activities matched expression changes of TN-R (Notch-regulated ECM protein) and CTSS, potentially aggravating blood-brain barrier disruption via Notch-dependent microglial activation [67, 68] (Fig

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As fibrosis affect the different compartments of the kidney, a comprehensive analysis of the renal ECM is crucial to study the pathophysiology of the disease and its specific biomarkers (Blow and Boor 2019)