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Our bodies dont create vitamin B12, so we receive it through diet and supplementation

doi: 10.1210/endo.135.5.7525254

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A randomized controlled trial in 167 older adults (50 years) found two-year supplementation with vitamin B 12 (10 g/day), along with folic acid (200 g/day), vitamin B6 (10 mg/day), riboflavin (5 mg/day), and vitamin D (10 g/day), had no effect on bone mineral density (total hip, femoral neck, or lumbar spine) compared to the control group only receiving vitamin D (10 g/day ) (116)

A single injection helps, but for a depleted person the effect may not last long