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Given the lifelong need for B12 therapy in deficiency-prone populations, the selection of the most patient-friendly and economically sustainable option is critical

But critics fear the FDAs stamp of approval will simply legitimize the use of unproven substances whose dangers may only become apparent in coming years

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The mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems

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