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The impact of reducing gastric pH with omeprazole on the PK of oral semaglutide has been assessed and this may cause a small but not clinically relevant increase in semaglutide exposure [19]

They found statistically significant improvement in skin whiteness/lightness (measured via colorimetry) compared with placebo

Breast Cancer Res 13:R97 Sabatier R, Finetti P, Cervera N, Lambaudie E, Esterni B, Mamessier E, Tallet A, Chabannon C, Extra JM, Jacquemier J et al (2011) A gene expression signature identifies two prognostic subgroups of basal breast cancer