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Mol Cell Endocrinol 458:615

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The reason for the increased blood volume is still unclear but one of the mechanisms under consideration relates to oestrogen activation of the renin-angiotensin-aldosterone system which promotes water and sodium retention and subsequently leads to hypervolemia (Reference Easterling, Benedetti and Schmucker24)

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Coenzyme Q10 is found in all cells of the body, with especially high concentrations in the mitochondria and heart, and Pyrroloquinoline Quinone is a naturally occurring salt compound