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In individuals with IBD, proinflammatory cytokines downregulate OCTN2 through the PPAR/RXR pathway, resulting in reduced carnitine uptake by intestinal epithelial cells that leads to the dysfunction of intestinal regeneration and repair and further deterioration of IBD [232]

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Dnm2 : Dynamin 2 (Dnm2) is a large GTPase mainly involved in membrane trafficking through its function in the formation and release of nascent vesicles from biological membranes

Its derivation from -MSH connects it to the melanocortin system, which plays important roles in inflammation resolution and tissue homeostasis

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